CBX2/M33 phosphorylation affects nuclear localization: high mobility (unmodified) CBX2 resides in the cytoplasm in mouse livers, whereas low mobility isoforms localize to the nucleus [ 46].
We first compared the localization and mobility of GFP-CXXCDnmt1 and GFP in mouse C2C12 myoblasts.
In order to gain insights into the pathogenic mechanism of the p.Cys134Trp mutation, the subcellular localization and mobility of the mutant protein were studied and found to be no different from those of the wild type (WT).
Specificity might also be directed at the protein level, through potential differences in localization or mobility within the apoplast.
Based on modern microscopy techniques that reveal the number, localization and mobility of Impβ molecules in the NPC the authors propose that impβ and Nup153 interact at the nuclear side of the NPC where they form a Ran-regulated meshwork.
Both proteins localize at SJs, show interdependence for localization and restricted mobility with known SJ members and are required for the integrity of epithelial barriers.
In addition, such frequent changes limit mobility, localization, roaming, and multihoming support on the Internet [121].
Different Quality of Service (QoS) metrics such as energy consumption, mobility, localization, optimal path calculation, data distribution among Fog devices and performance are measured in the simulated post-disaster model to evaluate the system.
Consequently, the work presented here successfully combines FCCS and PCH and FLIM to assess the intracellular localization, binding affinity, mobility, and composition of TLR9 and its ligands by estimating the diffusion time, number of molecules, fluorescence lifetime, brightness and stoichiometry of interaction (Figure 1a) in live single cells.
