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This diversity in Elk-1 cellular and subcellular localization implies diversity in Elk-1 function.
This localization implies that NcAP3m is a critical component of the secretory vesicle membrane and mediates extracellular enzyme secretion.
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Interestingly, treatment of cells with the microtubule depolymerizing reagent nocodazole or the dynein inhibitor EHNA both decreased Dp71d nuclear localization, implying that Dp71d nuclear import may be facilitated by microtubules and the motor protein dynein.
Our data indicates that VHL changes the behavior of MTs dependent on their subcellular localization implying a role for VHL in cellular processes such as migration, polarization, and cell cell interactions.
Taken together, the genes clustered together have similar gene structure and subcellular localization, implying Rab genes in the same class generally have similar functions.
Addition of zVAD-fmk mainly preserved the ZO-1 membrane localization, implying the involvement of caspases in the localization changes.
An N-terminal basic domain of Dia is crucial for apical localization, implying direct binding to PI 4,5 P2.
Non-metabolizable d-glucose analogues were also able to trigger the nuclear localization, implying that these sugars, except maltose, directly function as the inducers of AmyR nuclear entry.
These properties and specific localization imply that high INA in blueberry stems is of intrinsic origin and contributes to the spontaneous initiation of freezing in extracellular spaces of the bark by acting as a subfreezing temperature sensor.
It was also reported that the activity of Cdc42's guanine nucleotide exchange factor (GEF) and GTPase activating protein (GAP) are required for proper septin ring formation and localization, implying that one or more cycle(s) of nucleotide binding and hydrolysis are required for Cdc42 at the beginning of budding (Gladfelter et al., 2002; Caviston et al., 2003).
These localizations imply important roles of OsPIP water channels in the water transport of rice plants.
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