Recently, a rhomboid protease was identified in yeast mitochondria, where it is involved in processing of substrates localised to the mitochondrial intermembrane space[ 75].
As BACE1 and γ-secretase are localised at endosomes, amyloidogenic, neurotoxic processing of APP requires endocytosis [ 51– 54] and is controlled by vesicular trafficking [ 55].
Indeed, recent results show that proteins involved in the processing of miRNAs are localised to developing DRG axons and growth cones and to mature peripheral axons in vivo.
Midline localisation, periumbilical or poorly localised 2.
Heat-shock protein of 47 kDa is a collagen-binding, stress-inducible protein localised in the ER that participates in the intracellular processing, folding, assembly, and secretion of procollagens, especially in collagen-secreting cells, such as fibroblasts, for example, in fibrotic lesions (Razzaque and Taguchi, 1999).
We have previously reported that cells lacking key G4 processing enzymes, including REV1, FANCJ, WRN and BLM, exhibit localised epigenetic instability in the vicinity of G4 motifs (Sarkies et al., 2010, 2012).
Except Saha-UD, they are all closely linked (Region 1 in Figure 2) and are localised with PSMB8, PSMB9, TAP1 and TAP2 genes, which are involved in antigen processing and transportation.
The mouse vasa homologue (MVH) was discovered to play a role in RNA processing of both mRNAs and piRNAs in germ cells and to be localised to cytoplasmic granules some of which are closely associated with mitochondria [38], [52].
Ras p21 is an internally localised biosynthetic protein and is therefore potentially susceptible to the endogenous pathway of antigen processing and subsequent loading with MHC class I or II molecules.
As tBRD-1 proteins largely localised to Fibrillarin-deficient regions within the nucleolus this might argue against a role of tBRD-1 for ribosomal RNA processing.
