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Localised joint pain alone seems to be of less importance than joint pain at both the hip and knee, or joint pain in combination with other health problems.
Osteoarthritis (OA) is a chronic, localised joint disease affecting approximately one-third of adults, with the disease prevalence increasing with advancing age [ 1].
However, when we used the criterion of three or more referrals without requiring any specific MUS syndrome (search B), it identified three patients who on clinic assessment had localised joint pain as their main symptom.
Australia New Zealand Clinical Trials Registry ACTR12607000001493 Osteoarthritis (OA) is a chronic, localised joint disease affecting approximately one-third of adults, with the disease prevalence increasing with advancing age [ 1].
While these patients also reported other symptoms on the PHQ-14, it was the localised joint pain, which had the greatest effect on their functioning.
Although pain is often attributed to localised joint pathology, research has shown that pain intensity does not always correlate with the severity of joint structural damage or the presence of inflammation.
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Wipke et al. elegantly showed that, within minutes of intravenous injection, autoantibodies specifically localise to joints destined to become inflamed in the K/BxN mouse model of RA, even in the absence of pre-existing joint inflammation [ 58].
1CTP is preferentially localised in local joints [ 37] and tumour necrosis factor blockade inhibits activity of the 1CTP-generating MMPs [ 41].
RCTs testing t'ai chi against any type of controls in human patients with OA localised in any joints that assessed any type of clinical outcome measures were considered.
A large proportion of the B cells in the inflamed joint are localised in the synovial tissue, while they are a relatively small population among the synovial fluid cells (see supplementary figure 2, available online only).
It has been postulated that bacteria attached to the surface of prosthetic hip joints can cause localised inflammation, resulting in failure of the replacement joint.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com