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A failed MoM hip implant can cause both localised and systemic health problems, and symptoms such as hearing loss, dizziness, decline in cognitive function, cardiomyopathy and organ failure have been reported (Tower [2010]; Mao et al. [2011]).
We also assessed OPN levels in response to treatment in both localised and systemic disease.
To date, a definitive study of plasma OPN as a biomarker of increasing tumour aggression (bulk/stage, grade, PSA) across both localised and systemic disease has not been published.
In large cohorts, the pre- and posttreatment absolute value, and doubling time of PSA, may predict disease-free survival (DFS) and long-term response to localised and systemic treatment (Christensen et al, 2008; Wo et al, 2009).
Over time ASR hips have been implicated in a range of localised and systemic health problems including pain, inflammation, infection, tiredness, nausea, visual impairments, problems with mobility, tinnitus, heart palpitations and depression [ 10].
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However, controlled data for the use of rituximab in localised and early systemic disease are lacking at present.
Conversely, larger muscle mass exercise involves both a localised stimulus in the active muscle, and systemic hemodynamic stimulus by virtue of both increases in cardiac output and peripheral changes in the sympathetic vasomotor tone sub-serving the control of blood flow and distribution.
It's a societal and systemic thing.
The results have both strategic and systemic implications.
HAI - localised or systemic condition: 1) that results from adverse reaction to the presence of an infectious agent(s) or its toxin(s) and 2) that was present 48 h or more after hospital admission and not incubating at hospital admission time [ 17 ].
There are topical and systemic treatments available.
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