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Cortical or subcortical regions for which no connections could be found (due to a tracking failure) or for which no perfusion data could be obtained (due to localisation outside of the ASL imaging FoV) were excluded pairwise from the analysis (in Group 1 seven missing values in different regions, in Group 2 four missing values in two different regions).
Taken together, our overall data in breast cells suggest that CD44 localisation outside lipid rafts is associated with a pro-migratory state; furthermore, a range of CD44 binding partners was only ever recovered from nonraft domains.
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Fifteen patients (54%, 4 had CHT, 11 had no CHT) had lymphoma localisations outside the brain at PET total body examination.
Most patients (n = 30/42 i.e. 71 %) had liver only disease, while 12 patients had one or more tumour localisations outside the liver, mainly local lymphadenopathy (mainly in the hepatoduodenal ligament).
Pearson correlation coefficient analysis demonstrated a negative correlation of Nox4 and BHMT within the nuclear compartment, but significant co-localisation outside of the nucleus (Fig. 7F).
Also demonstrated clearly are effects through Tsbp4 on other integrin mediated events both inside and the cell (FAK phosphorylation and paxillin localisation) and outside the cell, laminin organisation.
However, localisation of CD44 outside lipid rafts in human glioblastoma cells has been shown to induce metalloproteinase-mediated CD44 shedding and tumour cell migration [ 31], which was further confirmed after membrane cholesterol modulation with methyl-β-cyclodextrin, filipin and simvastatin [ 32].
Midline localisation, periumbilical or poorly localised 2.
For example, in contrast to IκBα and IκBβ, the nuclear localisation signal on Bcl-3 lies outside the ankyrin repeat domain and enables transport of bound p50 p50 NFκB homodimers into the nucleus ([17] and references therein).
For each category, we considered whether the geographical localisation was in Italy (headquarters located in Italy) or outside the national borders (headquarters located outside Italy).
Localisation of cysts and SRF was categorised : (1) being outside the central mm and (2) involving the central mm.
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