Two known functions of KH-domain containing proteins are the regulation of mRNA stability and subcellular localisation, both of which are implicated in fundamental biological processes such as development, cell growth, differentiation and carcinogenesis (Ross et al, 1997).
We examined localisation of βPS, which is expressed in both midgut and VM cells, αPS1, which is expressed in the midgut cells, and αPS2, which is expressed in the VM (Bogaert et al., 1987; Leptin et al., 1989; Wehrli et al., 1993).
The blogger ends by suggesting a Sri Lankan "localisation" of "Equus," which he says would require "a mind mending work of cultural transition loaded with insane economic and political risk".
Clegg went on to emphasise his belief in decentralised government: "For new progressives, the localisation of power – which means, necessarily, of money – is one of the most urgent tasks facing us".
This study provides a pattern of localisation of lymphoma which will be valuable for radiologists in the differential diagnosis of orbital masses.
The fate of our women's refuges is in direct relation to the localisation of services, which has made a competitive business out of funding bids with many councils forced to put their services to tender to local housing associations.
EIF5A2 stabilized STAT3 and stimulated nuclear localisation of STAT3, which resulted in increasing enrichment of STAT3 onto TGF- β1 promoter to enhance the transcription of TGF- β1.
Five groups independently reported a nuclear localisation of Ptdsr, which clearly contradicts the hypothesis that the protein might function as a transmembrane receptor [ 57- 61].
This observation suggests that the quality of the downstream signal is determined by the subcellular localisation of Ras, which by implication regulates the interaction with downstream effectors.
Overexpression of EIF5A2 in BC cells elevated the stability of STAT3 and stimulated nuclear localisation of STAT3, which resulted in increasing enrichment of STAT3 onto TGF- β1 promoter to enhance its transcription.
