Localisation of high risk areas should also be evaluated, including determining the role of functional magnetic resonance imaging to target radioresistant subvolumes within the gross tumour.
Patient characteristics are summarised in Table 1, which also reports tumour localisation and risk of aggressive behaviour as proposed by Fletcher et al (Fletcher et al, 2002).
In this setting, all previously significant risk factors were excluded leaving localisation of primary in the appendix (HR=11.85, CI: 2.73 51.379, P=0.001) and T4-status (HR=1.825, CI: 1.22 2.73, P=0.003) as independent risk factors in the era of contemporary chemotherapy.
However, other risk factors like younger age and specific localisation of the primary tumour as well as factors that are associated with lower risk of developing PC are not included in the UICC staging system.
Tumours from familial melanoma syndromes have suggested that nuclear localisation of p16 might have a further role in risk stratification.
A combined prognostic analysis taking into account preoperative PSA levels, Gleason grade and nuclear localisation of NF- κB staining identified subsets of patients with markedly different risks of biochemical relapse.
The early localisation of new TBE foci and the identification of the main risk factors associated with disease emergence represent a priority for the public health community.
Based on these results, we conclude that increased expression, activity and subcellular localisation of Rac1 contribute to the limited response rate and higher risk of tumour recurrences in HNSCC patients.
Though the sample size is not large, the study also indicates that the risk of excretion of bacteria may depend on the localisation of infectious foci.
Surgery is the mainstay of curative therapies for rectal cancer patients, but the pelvic localisation of the rectum leads to surgical limits and thereby to an increased risk of local recurrence and poorer overall prognosis (Påhlman, 2005).
Increased expression, activity and subcellular localisation of Rac1 could be associated with lower early response rate and higher risk of tumour recurrences in HNSCC patients and warrants further validation in larger independent studies.
