Sentence examples for localisation of components from inspiring English sources

H3K27me3 is usually relatively dispersed compared with the discrete localisation of components of the PRC2 complex, which deposit this mark.

Finally, it is important to note that proteasome inhibition has been successfully used to rescue the expression and localisation of components of the DGC in skeletal muscle of mdx mice, and DMD and BDM explants, an effect obtained by reducing the elevated dismantling rate of disassembled proteins, which is due to the absence of dystrophin (Refs 140, 141, 142).

Accurate quantitative localisation of cell components is increasingly important in cell biological and signalling studies.

These data identify Notch signalling as a novel modulator of Shh signalling that acts mechanistically via regulation of ciliary localisation of key components of its transduction machinery.

Immunocytochemistry, and quantitative RT PCR was used to establish: (i) the presence and localisation of RAS components, (ii) the possibility of their involvement in cancer.

Last, quantitative approaches such as the new methods described here, provide the precision, sensitivity and unbiasedness that are prerequisites of sound quantitative localisation of cell components.

Taken together, these data demonstrate that Notch activity has a conserved, Shh-independent and significant effect upon localisation of key components of the Shh pathway within primary cilia, functioning at the level of the Ptch1/Smo interface to modulate ciliary localisation of these two signalling components.

This differential spatial localisation of two components of a canonical signalling cascade could provide a potential explanation for the antagonistic role of dystroglycan in opposing integrin-mediated ERK activation as above.

However, in contrast to CRM1, localisation of other components to the INB could not be inhibited by the drug leptomycin B (LMB), suggesting their recruitment occurs independently of CRM1 (Ernoult-Lange et al. 2009; own observation).

This role for Notch may also affect a broad range of other pathways that are reliant on ciliary localisation of signalling components in a wide variety of developmental and disease contexts.

Ofatumumab recognises a distinct epitope in close proximity to the plasma membrane, which is claimed to permit a more efficient localisation of complement components on the cell surface (Ruuls et al, 2008).