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While we typically do not speak on localisation matters, we feel the need to confirm that these jokes are not linked in the game and were never intended to be linked.
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In addition, as quantitation is subjective and subcellular localisation may matter (Cheuk and Chan, 2004), it would be desirable to have IHC findings reported carefully and in detail.
The first is that white matter localisation lacks the precision and consensus that grey matter analysis has been used to for some time, although there are some notable attempts to rectify this, for example by using post-mortem samples.
The WFU PickAtlas [23] was used as an anatomical reference to assess the exact localisation of gray matter changes.
Axonal localisation of these white matter tau aggregates in P301SBE mice was more readily visible in the ventral hippocampal commissure (observed in longitudinal section) where tau pathology had a similar severity to that observed in the fornix (Supplementary Fig. 5).
We show that the size of such error is sufficient to explain, for example, the surfeit of white matter localisations now crowding the literature.
Midline localisation, periumbilical or poorly localised 2.
Double labelling immunofluorescence of PrP with axons or myelin sheaths shows no co-localisation of granular white matter PrP with either structure in all three codon 129 genotypes.
Our study shows that filamentous white matter PrP deposition correlates with the localisation of the PRNP mutation and to some extent with the age of the patients.
No matter what stage at diagnosis or tumour localisation, the rate of patients receiving a surgical resection with curative intent within 6 months was higher in France than in England.
As a matter of fact, BCD affected the subcellular localisation of VDACs, leading the VDACs being mislocalised to vacuoles and ER, suggesting that membrane microdomains participate in membrane trafficking.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com