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The localisation index was three times higher for this specific antibody.
At this time point, the mean tumour/non-tumour tissue ratio was as high as 34.5, and the mean specific localisation index was 29.0.
The localisation index (LI) and the market share index (MSI) were calculated as measures of the health care utilisation and provision in each area.
We determined the Cortical Localisation Index (CLI, Figure 4 figure supplement 1), defined as the ratio between the mean GFP fluorescence intensity in the cortical region and the mean fluorescence intensity in the cytoplasm of the cell.
The localisation index (LI)[ 13], which quantifies the degree of primary care provided locally for the population in a given area, was also calculated and showed that on average 57% of all required primary care services were used from local physicians.
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Localisation indices and tumour:tissue ratios were superior for Mab 81C6.
The following clinical and biological variables were recorded: age, sex, body mass index, primary localisation, sites of metastasis, World Health Organisation (WHO) performance status (PS), Charlson comorbidity score (Charlson et al, 1987), haemoglobin, creatinin clearance (according to Cockroft method), alkaline phosphatase and carcinoembryonic antigen.
To elucidate further the role of cyclin D1 in prostate cancer, primary human prostate cancer specimens were utilised to assess the influence of cyclin D1 expression and localisation on PSA levels and proliferation index.
However, it should be noted that a number of cyclin D1-positive tumours in all three localisation groups had a low proliferative index, demonstrating that cyclin D1 expression itself is not sufficient to induce cellular proliferation.
The emergence of nuclear cyclin D1 in the high Gleason scores is intriguing, and this localisation pattern correlated with a higher proliferative index.
The baseline questionnaire is used to measure different patient characteristics (age, gender, race, social status, Body Mass Index (BMI)), disease related characteristics (localisation of symptoms, duration of symptoms, family history) and co-morbidities.
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