In order to confirm that the Mys localisation defect was due to a lack of Rac1 signalling, we overexpressed Rac1 in a homozygous Rac1J11 background [26], [28].
There is also no posterior GFP-Par-1 crescent in 38% (n=26) of rescued slmb/ slmb9H4-17 adults, which correlates well with the penetrance of the Staufen localisation defect in this mutant combination.
2. Clinical characteristics such as the localisation of defect and age of facial prosthesis are significantly associated with patients' QOL.
These findings are not surprising, because both the localisation of facial defects and difficulties with facial prostheses affect a person's physical functions, such as the ability to work, basic activities of daily living, mobility, and vitality [ 8, 15, 17].
Additional features, related to localisation along the defect are also identified.
Defects in the localisation of Cse4 might be anticipated to have this effect as conditional alleles of CSE4 have been observed to have the mitotic checkpoint unsatisfied (Glowczewski et al, 2000).
The PCNA sumoylation defect of siz1 SAPΔ) had previously been attributed to a defect in nuclear localisation or retention, possibly due to a lack of Siz1 association with the chromatin (Reindle et al, 2006).
The sensor array configuration enables the determination of the directional information of waves, therefore enhancing the ability of pipeline defect detection and localisation.
However, these lines are lethal and show also an ER localisation, which might indicate a defect in trafficking.
The same condition did not confer growth advantage to pcp1-18 consistentsistent with the fact that γ-TuC localisation is not the underlying defect in this mutant.
