Under these conditions, combining data sets from different origins may not be optimal to improve estimations of QTL localisations and effects.
The cytoplasmic sequestration of ZONAB by ZO-1 regulates its nuclear localisation and, hence, its effect on gene expression.
As with any other type of photosensitiser, the issues to consider whilst designing a TM complex as a photosensitiser include cell permeability, efficient absorption of NIR light for deeper penetration, preferential affinity to cancer cells over healthy cells, targeted intracellular localisation and lack of side effects.
The data can be used for appropriately designing large scale studies investigating methodological issues such as sources of variability and localisation of tDCS effects.
The results indicate that, in addition to geometric factors, pore fluid pressure gradients have important effects on strain localisation and fluid flow behaviour during fault reactivation.
As far as we know, there has not been a previous attempt to simulate the effects of spatial localisation and temporal scales of individuals in the modelling of biomolecular systems.
It is noted that previous studies using the tagged vectors had shown that the reporter genes had no effect on the localisation and expression pattern of the ATXN7 protein [28].
In addition, IPF-derived HLMFs demonstrate increased constitutive αSMA expression and Smad2/3 nuclear localisation, effects which are reversed by KCa3.1 inhibition [ 30].
Overall, the results can be summarised as follows: First, we demonstrate a very reassuring consistency in the spatial localisation of effects across scanners.
By contrast, the absence of SNX1 had no effect on endogenous SNX5 localisation and macropinosome biogenesis using macrophages from SNX1 knockout mice.
