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In cultured neurons, ß-actin is enriched at the leading edge of growth cones via an mRNA localization and local translation mechanism [4], [5].
We found that Syp was required for mRNA localization and local translation of gurken mRNA in oogenesis.
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Misra's ethnographic study examines how globally established scientific material is delivered locally through transnational exports and in turn how local translation feeds back to the global level [ 123].
The neuronal RNA binding protein NOVA regulates splicing, shuttles to the cytoplasm, and co-localizes with target transcripts in dendrites, suggesting links between splicing and local translation.
Whether local translation or microRNA-mediated mRNA degradation could serve to regulate subcellular localization and function of NF-κB in the nervous system is an open question.
Local translation of reporter mRNAs has demonstrated translation in dendrites at focal points called translational hotspots.
Local translation plays particularly important roles in distal neuronal compartments, and dysregulated RNA localization and translation cause defects in neuronal wiring and survival (Jung et al., 2014).
Kye, M. J. et al. SMN regulates axonal local translation via miR-183/mTOR pathway.
Evidence suggests that local translation is functionally indispensable for synaptic and behavioral plasticity12.
The choice of codons can influence local translation kinetics during protein synthesis.
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