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The hypersensitivity is mediated by local sensitization of nociceptors and involves immune response and changes in the central nervous system [ 35].
Scott et al concluded that insidious mechanical neck pain reflects segmental local sensitization whereas whiplash-associated neck pain reflects an augmented central pain processing mechanism, i.e., central sensitization [ 11].
Order of stimulation sites was counter-balanced to prevent ordering effects and exact stimulation sites were varied to prevent carryover effects due to spatial summation, local sensitization, or suppression of nociceptors.
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A 1 min break between each test procedure was planned in order to avoid local pain sensitization.
To avoid any local pain sensitization, the trial run tests were performed on the index finger, the subsequent actual testing was performed on the middle fingers.
In a very recent study, Hirth et al. (2013) actually provide good evidence for local nociceptor sensitization that is robust only 21 days after the initial NGF injection in a pig model.
We next addressed the concern that local or systemic sensitization to IL13-PE would negate the therapeutic efficacy of IL13-PE in the fibrotic lung.
Further research during the last two decades has demonstrated that sensitization and local inflammation in the dura mater can be elicited by various agents and stimulation paradigms [4].
It primes an environment to develop sensitization in local tissue.
We found that lack of community sensitization by local leaders on signs and symptoms of obstetric complications was negatively associated with high community involvement in obstetric emergencies' management.
Stress and the subsequent stimulation of inflammation (systemic and local) lead to increased sensitization of pain and further defects of stress response systems (vicious cycle of stress, pain, and inflammation).
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CEO of Professional Science Editing for Scientists @ prosciediting.com