Sentence examples for local repressive from inspiring English sources

We therefore tested whether this DNA methylation recovery mediated by DNMT1 would be regulated by local repressive histone modifications.

In addition, we recently showed that local repressive modifications at donor chromatin can diminish homologous recombination [12].

In proliferating myoblasts, MyoD is associated with histone deacetylases (HDACs), the histone methyltransferase Suv39h1 and heterochromatin protein HP1, and might actively inhibit expression of its target genes by inducing a local repressive chromatin structure [24], [28], [29].

Therefore, an alternative explanation for the reactivation of genes could be an indirect effect, as H3K9me3 is redistributed to the blocks, essentially reducing local repressive effects elsewhere.

These mechanisms could explain some of the lack of correlation between TF binding and apparent function: an activating TF could drive mRNAs in some cases, but repressive ncRNAs in other cases; the action of an activating TF could also be compromised by local repressive ncRNAs.

Given their clashing and sometimes self-contradictory missions — to obey local laws, repressive or not, and to ensure that information knows no bounds; to do no evil and to be everywhere in a sometimes evil world — Wong and her colleagues at Google seem to be working impressively to put the company's long-term commitment to free expression above its short-term financial interests.

This leads to histone acetylation and nucleosome remodeling around ZLD binding sites, which facilitates binding by other transcription factors, and in many other cases leads to additional deposition of histone marks including H3K4me1 while at the same time prevents local deposition of repressive histone mark H3K27me3 and presumably formation of repressive higher order chromatin structure.

The Kremlin has been trying to stamp out resistance there since the breakup of the Soviet Union — through two civil wars, a heavy-handed police presence, power-sharing with repressive local elites and huge cash transfers, among other tactics.

And Google, an internet giant that had been notoriously willing to tailor its services in China to repressive local regulations, has said it may quit the market (see article).

It was gone, cropped short by a Met hairdresser so Ms. Mattila could portray Beethoven's Leonore, the wife of a liberal-minded nobleman in late-18th-century Spain who has been imprisoned for vaguely specified reasons by a repressive local governor.

In most cities repressive local policies about drug use and stigmatization of HIV-infected persons resulted in IDUs being a "hidden" population.