Stable local repression of cell proliferation genes by the Rb family is clearly required for the entry and maintenance of senescence [ 23], but this process does not appear to require extensive global compaction of the genome in the form of highly developed SAHFs [ 42, 44].
These include a local replication enhancer that activates origin firing at DAFC-66D (Orr-Weaver et al. 1989), ORC-independent origin firing at DAFC-34B (Kim and Orr-Weaver 2011), and local repression of ORC binding and origin activity at DAFC-22B (Kim et al. 2011).
We suggest that effective local translational repression is vital for a neuron to ensure that proteins are only synthesized when and where needed.
Gene silencing mediated by repeats is a phenomenon observed in various diseases, where, for example, DNA around tandem repeats becomes heterochromatic, leading to decreased promoter accessibility and hence to local transcription repression.
Taken together, our data illustrate the profound impact of TEs on gene expression patterns and show how loss of the piRNA pathway triggers derepression of dozens of genes simply by a loss of local TE repression.
Just before Mr. Bush's announcement last week, Mr. Saeed said that "all operations by Kashmiris under Lashkar-e-Taiba's command have been carried out against the Indian Army with the sole purpose of protecting the local population from repression," and that any civilian casualties were "a regretful exception".
The data thus strongly suggest that G9a- and EZH2-mediated histone methylation is closely associated with DNA methylation and histone deacetylation and that G9a and EZH2 inhibition and knockdown lead to decreased recruitment of repressive chromatin modifiers to the COX-2 promoter and the switching of local epigenetic status from repression to activation.
Enron's $2.9 billion Dabhol power plant in India was in a controversy over excessive electricity charges and repression of local protests against the facility.
"Sometimes we feel we are used to Israeli oppression for a long time but a new generation is dealing with a new repression, a local one," she said.
In 1885 a second rebellion was instigated in response to the repression of local rule, but it was quashed and its leaders hanged or imprisoned.
The spiral of protests, the repression of local activists and the subsequent, larger protests in Khimki, a sprawl of malls and bedroom-apartment block communities bordering Moscow, became a prelude to the street demonstrations that later swept the capital.
