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The local repeat RFA rate was 3%.
The local repeat RFA rate for the individual renal tumour was 3%.
The local repeat structure of the indel region was examined in the 5 Kbp of flanking genomic regions on both sides (Fig. S4 (see Additional file 1)).
(ii) Bursts of transposon activity result in a dramatic increase of the local repeat density and thus, may induce large intrachromosomal rearrangements directly or indirectly by segmental duplications.
In the present cohort there was a local repeat RFA rate of 3%, local tumour progression rate of 2.5% and metastatic progression rate of 2%.
For instance, if an indel has occurred in a local repeat structure, the alignment algorithm has multiple possibilities to place the gap without changing the overall score of the alignment (see Figure 2a).
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However, this stimulus contains within it a local repeated phoneme, /b/, which potentially acts as a standard.
They could be detected using the link to GEvo, which permits high-resolution sequence comparison and facilitates detection of local repeats in the region.
There are three main classes of repetitive elements, namely, local repeats (tandem and satellite repeats) [ 9], interspersed repeats (transposons) and segmental duplications (duplicated genomic segments).
Together with identification of the sequence context around indels, the structural characteristics of local repeats proved to be useful for systematic understanding of their nature and origin.
This assertion is borne out by the absence of misalignment, duplicate reads, indels, short local repeats, and so forth in the majority of homozygous SNPs (supplementary table S5, Supplementary Material online).
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