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This allows the mapping of local reliability across different locations in the training set space, and thus allows identifying regions where the model has low reliability.
They also focus on local reliability, that is, truth-acquisition in scenarios linked to the specific scenario in question as opposed to truth-getting by a process or method over a wide range of cases.
However, in this approach, locations in the chemical space are characterized only according to local data density, whereas we hypothesize that a model's AD is a function of, not only the local data density, but also of the local reliability, i.e., the net effect of local precision and bias.
This fraction can be used as a local reliability estimator.
We calculated local reliability scores as training progressed.
On average, no training-related increases in local reliability score were detectable.
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At each iteration, we compute a set of parcellations from different modalities and fuse them based on their local reliabilities.
The core of the grid is a huge network of high-voltage lines that was built to bolster local power reliability but is now the interstate highway for trading vast amounts of power.
A (weak) assumption on local solver reliability is required to always ensure convergence.
By suitably controlling penalty parameters, the algorithm was proven to always converge under a proper assumption on local solver reliability.
Results from both datasets confirm the validity of RDN as a method to appropriately define the applicability domain of a QSAR, by allowing a robust mapping of local predictive reliability across chemical space.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com