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Local relapse.
As expected, the local relapse of tumor was appreciated 1 year after the R1 surgery.
In literature, a great variability of local relapse (LR) detection rate is reported.
However, local relapse also depends on the biological characteristics and interstitial spreading of cancer cell [4].
Local relapse after R1 surgery was controlled by chemoradiation for long term in the current case.
Local relapse of residual cancer cells was macroscopically appreciated as an inevitable consequence of R1 surgery.
Effective response after treatment was presented on follow-up imaging, although few local relapses were found.
However, the pathway/s involved in the process of breast cancer local relapse are not well understood.
However, this concept may lead to considerable treatment-related morbidity and does not prevent local relapse.
Its involvement is an independent prognostic factor for overall survival and local relapse-free survival of patients with NPC.
To our knowledge, no case with such late local relapse as our case has been reported to date.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com