Sentence examples for local progenitors from inspiring English sources
The absence of Map5, Olig2, and Sox2 immunoreactivity in bipolar-shaped cells does suggest that the newlyborn multipolar cells come from local progenitors in each cerebellar layer.
Accordingly, the absence of cell proliferation and markers of neurogenesis within the roof of the fourth ventricle also excludes a periventricular source, thus indicating that all cortical cells born in adult rabbits come from local progenitors.
Studies in humans, and in adolescent PEC reporter mice, support a paradigm where PECs function as local progenitors for podocytes [ 8– 10].
Our previous work suggested a regeneration process involving activation of local progenitors, but a reduced ability to regenerate in older animals.
In addition, recent findings fundamentally challenge the hypothesis that MSCs also derive from EMT or EndMT, and the existence of circulating fibrocytes, suggesting that local progenitors are the main cell type involved in repair.
There is mounting evidence showing that local progenitor cells function to renew injured and aged epithelial cells in anatomically different regions[8 11].
PL use for cell culture is described extensively in the literature and may provide some insight into its potential ability to stimulate local progenitor cells (Burnouf et al. 2016).
These cell types have clear advantages like differentiation potential as well as paracrine effects, which have been reported to play a crucial role in their beneficial properties, by promoting angiogenesis, stimulating local progenitor and mature cells, or regulating inflammation and immune cell functions (da Silva et al. 2009).
The physiologic turnover of the epithelium is usually considered to be initiated by local progenitor cells in each gland which can give rise to different specialized epithelial cells [1].
The discovery that alterations of circulating and/or local progenitor cells may mediate this complication could identify novel therapeutic strategies.
However, irradiation of progenitors in the soft tissues was found to be equally effective, suggesting that local progenitor cells are also of importance [ 40].
