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Interestingly, we did not observe any T1/T2/T2 ∗ decrease in local plaques, suggesting that no significant iron accumulation occurs in our cohort of patients.
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The concept on local plaque markers that are predictive for adverse cardiovascular events that originate elsewhere in the vascular system is currently explored.
In addition, patients with a history of myocardial infarction had lower levels of Cav-1, supporting the relation between local plaque levels of Cav-1 and vulnerability for vascular events.
The inflammatory cytokines promote smooth muscle proliferation that contributes to local plaque formation.
In conclusion, expression of both systemic and local plaque TLR4 may be one of the mechanisms responsible for the pathogenesis of AMI.
Donepezil and galantamine are selective for AChE inhibition, whereas rivastigmine provides an additional inhibitory action on BChE and might have an effect on local plaque toxicity.
In response, we investigated the composition of the local plaque environment at the aortic root to determine the relationship between size and stability of the atheromas in our model.
After accounting for global plaque-connectivity correlations across a network, we found negative correlations (rLOCAL, in small neighbourhoods of ∼100 voxels) between the local plaque distribution and intrinsic connectivity in several heteromodal networks, particularly in regions of high intrinsic connectivity (Fig. 3).
Analysis of local plaque environment composition at the aortic root demonstrated significantly decreased CD68+ macrophage infiltration, when comparing the average total stained area per mean lesion area, in L-4F plus pravastatin-treated mice compared to age-matched vehicle controls (6.2 ± 1.2% vs. 9.8 ± 0.8%; P = 0.002).
Elevated BACE1 and APP levels in plaque-associated presynaptic dystrophies could increase local peri-plaque Aβ generation and accelerate amyloid plaque growth in AD.
Patients suffering from PAD often have a reduced arterial flow to the lower limbs due to local atherosclerotic plaques in the middle-sized and larger arteries.
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