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We show that phosphorylation of myristoylated alanine-rich C kinase substrate by membrane-localized PKC constitutes a positive feedback that is sufficient for local pathway amplification.
The computation assumes a local pathway context for the gene is given.
While not exhaustive, it integrates salient elements of our local pathway to care.
Thus, physical interactions are highly informative of local pathway architecture but provide a less complete picture of functional modules or interconnections between them [ 4].
Intuitively, if a mutation influences the function of a focus gene (FG) it may create a particular signature on FG's local pathway neighborhood.
Interruptions of delivery noted here emphasise the importance of not just an agreed, standardised, local pathway, but also a named person in charge.
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Some clinicians thought that written safety netting materials should be tailored to the local area accordingly: "a bit more specific to the area as well, that would be good so it was, you know it takes into account sort of local pathways, what's available locally including things like the community children's nurses" (OOHS GP).
We argue that it is the room for and nature of such local pathways and strategies that will determine the sustainability outcomes of the ongoing transition and land use transformation in dryland areas across East Africa.
A strategy should identify the range of services available in a community and develop clear local pathways to care.
These findings emphasise the need to standardise local pathways, to allocate clear responsibilities and to monitor vaccination coverage.
Secondly, stroke CPGs had been used instrumentally by changing their behaviour or clinical practice, through embedding the guideline into local pathways or policies.
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CEO of Professional Science Editing for Scientists @ prosciediting.com