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In addition, local motility would not be detected with dye, thymidine analogue or retroviral labeling and static histological approaches.
Thus local motility of stem and progenitor cells, or even rare long-distance motility may have been missed with previous approaches.
Each motility module is correlated with a unique combination of cell edge dynamics, localization of the cytoskeletal protein VASP, traction-force generation, and response to inhibition of actin polymerization by cytochalasin D. We propose that regulatory pathways give rise to particular combinations of local motility modules, resulting in a global functional phase of the cell.
The effect of PPARγ ligands on local motility, their potential effect on FAs formation, and their anticancer effect on ovarian cancer cells is unclear and not well studied.
T cells localized within the TRC network, suggesting that TRC-derived CCL21 promotes T-cell attraction and local motility that is thought to be critical for efficient selection of the rare antigen-specific T cells in SLOs.
This increase may indicate a change in the chemical code and consequent changes in intestinal motility, because myenteric neurons of the mouse small intestine that contain nNOS are mostly inhibitory motor neurons (90%) that innervate the muscular layer and also descending interneurons (10%) [ 25] that are involved in local motility reflexes [ 26].
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In addition to relatively straight rostral movements we recently reported that approximately one third of SVZ cells exhibit local exploratory motility [7].
The results presented here show that rather than a local regulator of motility and alginate production, AmrZ is a global regulator which may affect the transcription of hundreds of genes all along the chromosome.
Roundness is a measure of loss of the round organoid phenotype (Roundness), and is associated with invasive properties, whereas roughness of the segmented structures (Roughness), and severity of cellular protrusions emerging from the core structure (AppIndex), both relate to local invasion and cell motility.
Recently, local exploratory SVZ cell motility was seen in nestin-GFP and Gad-GFP mice [7].
Rho kinases (ROCKs) mediate cell contraction, local adhesion, and cell motility, which are considered to be important in cell differentiation.
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