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Colorectal cancer (CRC) progression is associated with suppression of host cell-mediated immunity and local immune escape mechanisms.
The components of Kampo medicines may affect general immunity indirectly, presumably through interaction with the gut local immune system.
MFG-E8 enhances tumor cell survival, invasion, and angiogenesis, and contributes to local immune suppression.
However, studies in cancer immunotherapy have focused heavily on local immune responses in the tumor microenvironment.
HLA (human leukocyte antigen) participates in the local immune response to prevent tumor invasion and progression.
MPA used as a contraceptive has been implicated in effects on local immune function.
Local immune dysfunction is thought to permit opportunist infection in canine SNA.
We investigated the nature of the local immune response mounted in canine sino-nasal aspergillosis.
Together, our data suggest that the glucose-restricted tumour microenvironment induces metabolically adapted, oxidative neutrophils to maintain local immune suppression.
Transgene effects include direct tumour-cell killing, promotion of local immune responses, oncolytic virus production, and prodrug activation schemes.
We hypothesized that 70-kd heat shock protein in mid-trimester amniotic fluid might regulate local immune system activation.
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