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Thus the large-scale evolutionary integration of sequence-structure-function data, here through reciprocal identification of local, functionally important structural features, may contribute significantly to de-orphaning the structural proteome.
Each significant polygon could be considered as the center of a local, functionally similar cluster of neurons.
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This theory is supported by recent clinical evidence demonstrating that worsening amyloidosis is correlated to worsening hypometabolism in both local and functionally related regions [ 56].
The segment length relevant for the analysis of local stress is functionally dependent on geometrical parameters of the girder cross section, area of action and size of load.
Local condensation in functionally or morphologically suspicious areas can enhance spatial resolution without unreasonably extending the examination duration [ 30].
We observed enriched GO-terms for lincRNAs containing predicted local motifs likely functionally 'linc'-ing these transcripts to vital processes of the human nervous system.
The retention of ohnologs and local duplicates is functionally biased and often reciprocal in many gene families: WGDs tend to retain transcription factors, whereas local duplicates tend to retain the genes functioning in stress response (Freeling 2009; Rodgers-Melnick et al. 2012).
When sequence or structure comparisons fail to suggest a function, insights can come from discovery of functionally important local structural patterns.
It can be of special interest given the pace of structures production on structural genomic initiatives worldwide, where functional insights can come from discovery of functionally important local structural patterns.
Each of these induced cell types survive, mature, and integrate into the local environment in a functionally meaningful manner.
The 'on-system' highway network excludes county roads, local city streets, and functionally classified city streets, which the district office is usually not responsible for.
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