local folding of

USAGE SUMMARY

The phrase "local folding of" is correct and usable in written English.
It can be used in contexts related to biology, particularly in discussions about protein structure or molecular biology. Example: "The local folding of the protein is crucial for its function and stability."

✓ Grammatically correct

Science

Human-verified examples from authoritative sources

Exact Expressions

9 human-written examples

Next, it is determined if the mutated protein exhibited reduction in SASA and local folding of nuclear localization signal residues RRR to predict loss of nuclear translocation activity.

F1000Research

The two attributes, such as local folding of nuclear localization signal residues RRR and reduction of SASA, derived from the simulation data suggest that the L35P mutant will exhibit loss of nuclear translocation activity while WT-ANG and K17I mutant will retain this activity.

F1000Research

We suggest that while the local folding of chromatin can be regulated at the fiber level by adjustment of internal factors such as linker-histone binding affinities, linker DNA lengths, and divalent ion levels, hierarchical looping on the gene level can additionally be controlled by posttranslational modifications and external factors such as polycomb group proteins.

Biophysical Journal

This is calculated per vertex of the cortical reconstruction for a patch of 25 mm, generating a centimeter-scale measure of the local folding of the cortex.

Cerebral Cortex

Ensemble free energies were calculated using a partition function approach assuming global folding of the ncRNA and local folding of the mRNA.

Genome Medicine

Two of these, involving either the local folding of a helix or dimerization, lead to structural features that are found in the native state of the mature metallated protein.

eLife

Human-verified similar examples from authoritative sources

Similar Expressions

51 human-written examples

We calculated this significance by comparing our folding-energy results with a distribution of folding energies for a 1000 randomly generated set of peptides sharing the same length and composition as the local fold of our proteins.

BMC Evolutionary Biology

It fits well with the fly-casting model as it only implies a local folding and not folding of the whole molecule to promote subunit association.

Plosone

It was observed that L35P had a reduction in SASA compared to WT-ANG and the K17I mutant, as a result of local folding and close packing of nuclear localization signal residues RRR.

F1000Research

Earlier studies conducted by us have established that local folding and close packing of nuclear localization signal residues RRR are responsible for loss of nuclear translocation activity of ANG mutants.

F1000Research

Large deviations of the calculated buried ΔAnp from the observed buried ΔAnp in the structure of complexes indicate significant effect of local folding upon binding, e.g. induced-fit.

Plosone

Expert writing Tips

Best practice

When discussing protein or RNA structures, use "local folding of" to specifically indicate that the folding process is occurring within a limited area or region of the molecule, rather than the entire structure.

Common error

Avoid using "local folding of" when describing the overall or global folding of a structure. This phrase is best reserved for situations where you want to emphasize that only a specific part of the structure is undergoing conformational changes, which can misrepresent the actual folding process.

Linguistic Context

The phrase "local folding of" functions as a noun phrase, typically used as a subject or object in a sentence. It describes a specific type of folding process limited to a particular area or region. As Ludwig AI confirms, it's usable and correct.

Expression frequency: Rare

Frequent in

Science

100%

Less common in

News & Media

0%

Formal & Business

0%

Ludwig's WRAP-UP

In summary, "local folding of" is a grammatically sound noun phrase used to describe the folding process occurring within a confined area of a structure, typically in a scientific or academic context. As Ludwig AI confirms the phrase is valid and helpful for discussions needing specification and emphasis on regional activity. While not exceptionally common, its use is precise and important for conveying specific structural dynamics in relevant fields. Consider alternatives like "localized folding of" depending on the area you want to address.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

localized folding of

Replaces "local" with "localized", emphasizing the confinement of the folding process to a specific area.

regional folding of

Uses "regional" instead of "local", suggesting a slightly broader area than "local", but still confined to a specific region.

segmental folding of

Focuses on the folding occurring within a specific segment or part of a structure.

partial folding of

Highlights that only a portion of the structure is undergoing folding.

limited folding of

Emphasizes the restricted nature of the folding process, suggesting it doesn't involve the entire structure.

folding in a specific area

Rephrases the concept to highlight that the folding happens in a specific location, avoiding the term "local".

folding within a defined region

Similar to the previous phrase, but explicitly mentions a "defined region" instead of using "local".

folding at a particular site

Shifts the focus to a precise location where folding is occurring.

folding in proximity to

Indicates the folding occurring near a specific point or area.

folding confined to

Highlights that the folding is limited or restricted to a particular boundary.

FAQs

How is "local folding of" different from global folding?

"Local folding of" refers to the folding process occurring in a specific, limited region of a molecule, while global folding involves the entire structure. Global folding determines the overall three-dimensional shape, whereas local folding describes arrangements within specific parts.

In what contexts is it appropriate to use the term "local folding of"?

Use "local folding of" when discussing specific regions of proteins, RNA, or other molecules that undergo folding independently or differently from the overall structure. This is common in discussions of protein domains or RNA secondary structures.

What are some alternatives to "local folding of" that I can use?

Depending on the context, you might use "localized folding of" or "regional folding of". These alternatives emphasize that the folding is confined to a particular area.

Why is understanding "local folding of" important in molecular biology?

Understanding "local folding of" is crucial because the local structure often determines the function of specific regions within a molecule. For example, the local folding of a protein's active site dictates its ability to bind substrates and catalyze reactions.