As localization, structure and function of many membrane proteins, enzymes and receptors depend on the cell membrane properties [9], such as fluidity and local curvature, the biological versatility of NSAIDs can potentially originate from their ability to interact with the lipid constituents of membranes.
Both local contexts and global fluidity, both entrenched power relations and opportunities for autonomy, and both subversion and transformation are acknowledged to be at play, sometimes within the same setting.
Another study demonstrated that use of the local anesthetic xylocaine affected the fluidity of the cell plasma membrane, in turn affecting HIV-1 infectivity (Harada et al. 2005).
We conclude that the homeostatic mechanisms that preserve normal membrane function vary: (1) with the nature of the stress that perturbs fluidity, (2) with local conditions within each tissue, and (3) possibly with the thermal tolerance of individual species.
The twists about the single bonds may well be modulated by the local electric field and membrane fluidity.
Owing to the resulting local changes in lipophilicity, thickness and fluidity, the plasma membrane permeability for amphiphilic drugs would then specifically be facilitated.
This model implies local differences in lipophilicity and membrane fluidity, which in turn might determine the site and efficiency of cellular drug entry.
Since the local electric field changes and membrane fluidity are not kinetically coupled, the fluorescence lifetime distribution of DASPMI is obscured.
Our observations of faster recoveries of fluorescence in PVM after local photobleaching are consistent with higher fluidity and more rapid lateral probe movement in membranes with lower cholesterol levels.
"The concept of the building is collaboration and fluidity," an Apple exec told local planners.
NE portions connecting two adjacent LADs may act as mechanosensors of local chromosomal forces and undergo changes in membrane fluidity and/or curvature.
