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We will discuss the application of lDDT for assessing local correctness of models, including stereochemical plausibility.
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This measure (the CORE index; Notredame and Abergel, 2003) not only estimates the agreement among the various methods (Fig. 2) in a graphical way but it also gives precious indication on the local structural correctness (Lassmann and Sonnhammer, 2005a; Notredame and Abergel, 2003) and can therefore be considered as a good predictor of alignment accuracy.
Particularly revealing is a lament from Macmillan in 1952 that, "in deference to modern political thought" (or what would now be called "political correctness"), his local church had omitted the third verse of "All things bright and beautiful": "The rich man in his castle / The poor man at his gate / God made them high or lowly / And ordered their estate".
Even in the case of globally optimized alignments by maximum matching approach, correctness of local alignment is not always guaranteed (Brudno et al. 2004).
The mobility script generated by VSG tool is verified in the local simulation mode to ensure the correctness of data exchange controlled by the operation rules.
One side sees the Indian mascot as a racist stereotype; the other sees a symbol of local pride under attack by the political correctness militia.
With the global and local information, the detection procedure enhances the correctness of salient object gradually.
This score summarizes aspects of local accuracy, overall assembly performance, and structural correctness at the scaffold level.
In CASP8, several scores for assessing the local modeling quality were introduced (main chain reality score, hydrogen bond correctness, rotamer correctness and side-chain positioning) (Keedy et al., 2009), as well as an evaluation of the stereochemical realism and plausibility of models using the MolProbity score (Chen et al., 2010).
Semantic correctness encompasses three properties: ensuring that local and global integrity constraints are maintained, that transactions output consistent data and that all partially executed transactions can complete.
We also found that, when allowing only 100 kb between scaffolded contigs (section 2.6), the assessed scaffold correctness was 70.6% and the local scaffold correctness was 90.3%.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com