A King on her mother's side, she is also a true-blue Bonacker, with local ancestry dating back centuries.
Many French and German Jews are immigrants, from north Africa or the former Soviet Union, but Hungarian Jews can trace their local ancestry back centuries.
The local ancestry estimate at LPA was improved by forcing rs9457951 into the set of markers used to estimate local ancestry.
Similarly, rs9457951 explains a large proportion of the LPA local ancestry signal in DHS.
To eliminate added confounding by ancestry we included local ancestry estimates in the regression model.
For genotype-phenotype association analyses, we assumed an additive mode of inheritance and tested for the strength of association by ANOVA [33] with nested linear regression models, which included global ancestry, local ancestry, and local ancestry + genotype.
Furthermore, inclusion of the LPA local ancestry rendered the overall ancestry term non-significant, suggesting that local ancestry at LPA almost fully explains the ancestry-related differences in Lp(a) levels.
Pairwise LD values in the African and European local ancestry subpopulations are shown in Figures 3 and Figure S1.
SNP-Lp(a) associations were evaluated by linear regression, correcting for global and local ancestry at the LPA locus.
Yet, when all three markers are included in the logistic regression, with age, individual and local ancestry as covariates, only rs12827748 exhibits a significant association (p = 0.03).
The program generates local ancestry estimates by integrating information from a panel of densely spaced markers differentiated in frequency between African and European populations.
