Exact(4)
Remote loading of liposomes by trans-membrane gradients is used to achieve therapeutically efficacious intra-liposome concentrations of drugs.
Remote loading of liposomes by transmembrane gradients is one of the best approaches for achieving the high enough drug level per liposome required for the liposomal drug to be therapeutically efficacious.
This procedure resulted in the loading of liposomes with dye.
Loading of liposomes on the L1 chip was carried out as described (Anderluh et al, 2005).
Similar(56)
The loading capacity of liposomes was evaluated after removing the free gemcitabine (centrifugation at 14000 × g for 1 h at 4°C) from the vesicular colloidal suspension coming from the re-suspension of freeze-dried liposomes.
For passive loading of the liposomes with microcystin, 500 μl of this suspension were added to 3 μg MC-LR and incubated for four h at 60°C.
GTP loading of ARF1, liposome pull-down assays, and GAP assays were conducted as previously described (Selyunin et al., 2011).
This enabled the passive loading of FOA into liposomes at a high concentration.
Previously we have developed and statistically validated Quantitative Structure Property Relationship (QSPR) models that correlate drugs' structural, physical and chemical properties as well as experimental conditions with the relative efficiency of remote loading of drugs into liposomes (Cern et al., J. Control. Release 160 (2012) 147-157).
In our design, carfilzomib was loaded into the bilayer of liposomes to yield stable and reproducible liposomal nanoparticles.
We therefore studied GTP loading in the presence of liposomes of different diameters.
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