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Using this approach we and the group of Sebastian Amigorena showed that to get to the site of Ii processing and peptide loading, class II MHC/Ii complexes must pass through transferrin receptor positive endosomes but that peptide loading itself occurs in later compartments [32, 33].
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The role of tapasin in the stabilisation and retention of empty or suboptimally loaded class I molecules and the facilitation of the loading of these molecules with more appropriate ligands is discussed.
Kalong must provide functions to serialize and deserialize agents; it must define a class-loader object for each agent, which directs requests to load classes back to Kalong.
The antigen processing genes TAP1, TAP2, PSMB8, and PSMB9, which process peptides for loading onto class I genes, are located in the class II region.
This heterodimer has been shown as the functional unit for loading MHC class I molecules with high-affinity peptides [ 30].
DR1 multimers, developed by loading empty class II molecules with exogenous peptide, provide a method for visualizing antigen-specific T cells with flow cytometry.
In this pathway processing within phagosomes or endosomes generates suitable peptides for loading onto class I MHC molecules present in those compartments.
Load class description from I/O buffer and return class object.
Shares offered with a front-end load are commonly called "Class A shares," and those with a back-end load "Class B shares". A fund's performance figures and NAVs will be different for different share classes.
Funds have other expenses beyond 12b-1 fees, of course, and in many cases these are also higher for the deferred-load class than for the front-end-load or no-load versions.
Class A shares typically charge an up-front sales load; Class B shares tack on the fee when you sell the fund.
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