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These findings have several implications for understanding the role of bioenergetic changes in LOAD pathology and aging.
Because LOAD causes profound neuronal cell loss and astrogliosis that will alter mRNA levels in affected regions, mRNAs were measured in the cerebellum which is largely unaffected by LOAD pathology.
The similarities between EOAD and LOAD pathology are integral to the amyloid hypothesis.
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Comparisons concerning tissue bacterial load and pathology scores involved only those animals that died.
Preceding the reduction in viral load and pathology, these responses were probably important for viral clearance and recovery.
High responder (HR) fish were characterized with sustained and increased viral load and pathology in heart tissue.
Activation of these responses was preceding a reduction in viral load and pathology, suggesting that they were important for viral clearance and recovery.
Rapp et al. [ 27] reported that the load of pathology in subjects with AD was significantly higher in those who had suffered from a lifetime history of depression, thus, suggesting an association between these two disorders.
Even when the innate immune response cannot eliminate a virus, it may substantially reduce viral load, reduce pathology, facilitate clearing of the virus by the adaptive immune response, and slow the spread of infection (1 ).
Correlation between monocyte caspase-3 activity and ex vivo production of TNFα by monocytes, as well as between organ bacterial load and pathology scores were performed according to Spearman.
Microbiological, histological, and flow cytometry examinations revealed that all mice displayed a range of Mtb loads, lung pathology, and lung cell viability (Figure 1 B F).
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