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Transcriptional inheritance is the load of transcripts and active genes that are passed to the subsequent step of differentiation.
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It has been suggested that purine-loading of transcripts may have evolved to prevent detrimental RNA-RNA interactions [ 20].
For example, in murine ESCs, 'parsimonious translation' is hypothesized to define the pluripotent state, with undifferentiated ESCs containing 78% lower ribosome loading of RNA transcripts relative to their differentiated progeny, which establishes an RNA pool of specific transcripts that do not undergo productive protein synthesis (41).
One possibility is that all organisms contain a background load of PTC-containing transcripts, arising from inheritance or by sporadic errors in transcription or splicing, and that the NMD pathway is required to eliminate these erroneous mRNAs to maintain normal cellular function (Neu-Yilik et al. 2004).
Generation of transcripts.
It is easy to see that instability of m a reduces the amount of transcript loaded for translation and reduces the overall translation rate.
Similar to mammals, zebrafish embryos progress through the maternal-to-zygotic transition (MZT) in two phases: rapid degradation of maternally loaded transcripts, and minor and major waves of zygotic genome activation (Tadros and Lipshitz 2009).
This analysis shows that the abundance of many maternally loaded polyadenylated transcripts declines after late blastula.
The most significant changes in MeV's architecture have been adjustments to its data model that allow loading of read counts, normalized transcript expression levels, transcript lengths and read library sizes.
Early development in amphibians and other organisms is regulated by maternally loaded RNA transcripts until the point of zygotic activation during the maternal-zygotic transition.
What a load of baloney.
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