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The researchers estimate that the total load of newly formed dust in the remnant is about 25% as massive as our sun.
Second, attenuation of global protein translation to reduce the load of newly synthesized proteins and prevent excessive accumulation of unfolded proteins [15], [16].
When the load of newly synthesized proteins exceeds the folding and/or processing capacity of the organelle, the ER enters into a stress condition.
The UPR system is involved in balancing the load of newly synthesized proteins with the capacity of the ER to facilitate their maturation.
In this way, PERK activation results in a quick reduction in the load of newly synthesized proteins that are translocated into the ER-lumen (Harding et al., 2000).
PERK mediates inhibition of global protein translation through phosphorylation of eukaryotic translation initiation factor 2 α (eIF2 α), which reduces the load of newly synthesised proteins entering the ER lumen (Shi et al, 1998; Harding et al, 1999).
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That's where I found Sophie Theriault the other morning, sorting through loads of newly arrived pants and shirts.
Defective loading of newly synthesized CENP-A is paralleled by (and may result from) a reduced recruitment of the CENP-A-specific histone chaperone HJURP.
Macropinocytosis has been previously shown to deliver antigens for lysosomal processing and loading of newly synthesized MHC class II molecules in DCs [ 50, 51] and macrophages [ 28].
Currently, a three-step mechanism loosely describes the process: (1) recognition and licensing of centromeres, (2) loading of newly synthesized CENP-A with the help of chaperone proteins, and (3) maintenance of newly incorporated CENP-A (Fig. 3a).
Loading of newly synthesized CENP-A with the help of chaperone proteins There have been two factors identified that stabilize the CENP-A/H4 complex, RbAp46/48 (Mis16, a member of the CAF-1 complex) and HJURP (or SCM3 in yeast).
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