Type two diabetes mellitus, for example, can be understood in terms of altered insulin release by the pancreatic beta cell and impaired action via its receptor and signalling cascade (proximate causation); or as a mismatch between evolved biology and the evolutionarily novel nutritional and energetic environments in which most humans now live (ultimate causation).
"These are people who are willing to send their loved ones off to perhaps give their lives, the ultimate sacrifice.
But both studies so far have narrowly missed showing that the drug can prolong lives, the ultimate test of a cancer drug.
Eventually, Google will also design and develop new wearable technology to monitor the health of participants in the study, providing more data on things like heart rate, blood pressure and possibly going as far as body chemistry as they go about their daily lives – the ultimate quantified self.
For sports fans, Roku streams live and on-demand sports from NBA Game Time, NHL GameCenter Live and Ultimate Fighting Championship.
Tiina Laakkonen has lived the ultimate life in fashion: model to William Klein, assistant to Karl Lagerfeld, stylist to top fashion magazines (including T).
Armed with the 15-page index to "The Way We Live: An Ultimate Treasury for Global Design Inspiration," with about 1,000 photos by Gilles de Chabaneix and text by Stafford Cliff (Clarkson Potter, $75), you can scan versions from Mauritius to Oaxaca.
Howard has been somewhat redeemed by living the ultimate nerd fantasy — becoming an astronaut — but even more by the love of a good woman, Bernadette (Melissa Rauch), whose oft-remarked-upon "ample bosom" is overshadowed by the fact that she's smarter than he is and makes more money.
Tauscher may be living the ultimate instate football fantasy, but Seubert will not even admit to having ever been a Packers fan, and is not the least bit torn about his wish for Michael Strahan & Company on the defensive line to fillet and fry the state icon Brett Favre.
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