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The frequency of STRO-1-positive cells in adjacent tissue appears low (mean ± SD: 11 ± 8 positive cells per view, n = 12), except for livers with extensive inflammation (Supplementary Figure 2, available at Carcinogenesis Online).
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Transgene expression can be detected in the host liver with extensive intratumoral injection of the mc-CMV-IFNγ (Figure 6A and B), which raises a concern about potential systemic cytotoxicity.
Hepatocellular carcinoma is usually present in inflamed fibrotic and/or cirrhotic liver with extensive leukocyte infiltration.
(a) Macroscopic view of ex vivo liver tissue with extensive tumour infiltration, including viable (blue box) and necrotic (white box) areas.
The reference standard for diagnosis of cirrhosis was histological evidence of irreversible chronic injury to liver parenchyma with extensive fibrosis and formation of regenerative nodules.
Thioacetamide-intoxicated rats developed liver cirrhosis with extensive deposition of scar tissue in expanding fibrotic septa showing typical extensive bridged fibrosis, in which collagen types I and III (CI and CIII) predominate.
In arm B, one patient with extensive liver metastasis died of liver failure 3 days after the first application of chemotherapy, a second patient died of neutropenic sepsis 17 days after the first application of chemotherapy.
Also, tumour progression seemed to slow down and liver masses decreased in size after chemotherapy in two patients with extensive liver disease and lung metastases.
Biochemistry: Expressed as mean values ± s(n –1) Histology: Liver: Centrilobular necrosis was prominent on the surface of the liver at 24 h, with extensive severe coagulative necrosis at 48 h.
Twenty years ago, a close family member was diagnosed at the age of 54 with colon cancer with extensive liver metastases.
The two minor responses occurred with doses of gemcitabine of 0.5 and 3.0 g m−2 in patients with extensive liver metastases.
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