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To examine the effect of PEG 35 in liver injury after normothermic perfusion, fatty livers were randomized in the following groups: (1) Control group (Ctr 2) (n = 4): after procurement, steatotic livers were ex vivo perfused for 2 h at 37°C as described above, without prior cold storage.
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In this randomized controlled trial 26 patients undergoing liver resections for liver tumours were randomized to immunonutrition and control groups each consisting of 13 patients.
In a follow-up study by the same group of investigators 30 patients with liver cirrhosis were randomized to receive either Synbiotic 2000 or placebo (crystalline cellulose ) for 7 days [63].
In the new Early Presentation Of Cancer Project (EPOC) study, 272 patients with KRAS wild-type (wt) tumor operable liver metastases were randomized to receive FOLFOX plus or minus cetuximab for 12 weeks before, then 12 weeks following, surgery.
Liver transplant patients were randomized at 4 weeks to start everolimus and discontinue CNI, or continue their current CNI-based regimen.
Thus, 80 patients with unresectable CRC and liver-only metastases were randomized to receive BEV plus mFOLFOX6 (modified fluorouracil, folinic acid, and oxaliplatin) or BEV plus FOLFOXIRI (fluorouracil, folinic acid, oxaliplatin, and irinotecan) every 2 weeks.
PROTECT was a multicenter, prospective, open-label, parallel-group trial in which de novo liver transplant patients were randomized at 4 weeks posttransplant in a 1 1 ratio to start everolimus and discontinue CNI therapy, or to continue their current CNI-based regimen (NCT NCT00378014).
In a prospective, multicenter, open-label study, de novo liver transplant patients were randomized at day 30±5 to (i) everolimus initiation with tacrolimus elimination (TAC Elimination) (ii) everolimus initiation with reduced-exposure tacrolimus (EVR+Reduced TAC) or (iii) standard-exposure tacrolimus (TAC Control).
8 patients were withdrawn because of progressive liver dysfunction; 83 patients were randomized to standard treatment with or without pravastatin.
In the recent H2304 trial, de novo liver transplant patients who were randomized to everolimus with tacrolimus elimination and who continued on this regimen showed strikingly good renal function at 2 years posttransplant 10.
Ten patients submitted to liver dialysis using the Molecular Adsorbents Recirculating System (MARS) were randomized in an open-label crossover trial of regional citrate anticoagulation versus anticoagulation-free liver dialysis [ 40].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com