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Mice were anaesthetized with isoflurane and livers were exposed through a midline laparotomy.
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HMs, in injured livers, are exposed to multiple cytokines and inflammatory mediators, including TNF-α.
Indeed it is surprising, given the noxious chemicals that the liver is exposed to, that more drugs do not damage it.
"I believe that the reason is the extensive and recurring injury that the liver was exposed to in evolution: rotten food, plant toxins, viruses," says Markus Grompe, a liver expert at the Oregon Health and Science University.
The liver was exposed by a limited abdominal incision and approximately 100 µg of RNA inoculated directly into the liver.
The liver is exposed continuously to a diverse and large antigenic load, including pathogens, toxins, and tumor cells, as well as dietary and commensal proteins.
Liver injury and death are the major hallmarks in all liver diseases [15] and it is during these conditions that the liver is exposed to increased levels of TNFα apart from other inflammatory cytokines.
The liver was exposed by subxiphoid laparotomy.
The liver was exposed via an anterior right subcostal incision.
A 3-cm midline incision was performed and the hilum of the liver was exposed.
After median laparotomy, the hilum of the liver was exposed to access the portal vein.
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