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Neither STAT-3 nor pSTAT-3 levels in hepatocytes and the livers were altered by rHu-EPO (data not shown).
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For example, the preferential activation of p54 by 3-NPA, an inhibitor of succinic dehydrogenase (ETC CII), in young C57BL/6 mouse livers is altered in aged mice [ 19].
The decrease in glycogen and increase in fatty acid uptake in response to PB suggested that the proportions of fat and carbohydrate in the liver were altered.
Boll et al. (1998) demonstrated that gluconeogenic enzymes in rat liver are altered after PCB exposure.
We have used a drastic approach, that is the knockout of the miRNA biogenesis factor Dicer (Harfe et al., 2005), to assess how the rhythmic transcriptome in mouse liver is altered in the absence of miRNA-mediated regulation.
This corresponded to the time curve of GADD34, ABAT and SULT1A1 RNA levels in the liver: RNA levels were altered 1, 6 and 12 h after methapyrilene administration but return to control levels after 24 and 72 h (Schug et al. 2012).
We observed that oscillations in NAD+ levels were altered in the liver of CD38-KO mice.
Liver transcripts that were found to be altered with WD feeding were subsequently entered into Ingenuity Pathway Analysis (Qiagen) to elucidate gene networks and/or biological functions within the liver that were altered.
Copper and Zn concentrations in kidney and liver of LWF were altered.
The primary outcomes were altered liver function, measured by the model for end-stage liver disease (MELD) score, and total bilirubin and prothrombin time International Normalized Ratio (PT-INR), 5 days after CPDF therapy.
Further, Akt/GSK3/cyclin D1 signaling pathways in the liver of treated mice were altered, which may help prevent homocysteine-induced cell cycle dysfunction.
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