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Against a background of prediction reports involving unmatched clinical subjects and liver donors, a direct comparison of CLint between microsomes and hepatocytes from the same livers was reported by Foster et al. (2012).
In addition, the hyperacetylation of histone H3 on lysine 9 (H3K9and and of histone H4 on lysine 8 (H4K8ac) in HCC compared to cirrhotic and normal livers was reported [ 38].
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Recently, a malignant AML in the liver was reported.
Little effect of overlap between the heart and the liver was reported by McQuaid and Hutton [24].
For the selection of the liver toxicity data to be used for modeling, we considered the compounds for which LOAEL related to effects on liver was reported and we labelled them as "active" substances.
Liver was reported to be the most common site of the GIST metastasis.
Endocrine regulation of this pathway in the zebrafish liver was reported previously after EE2 treatment [ 43].
16 In addition, the histology of the TAA-exposed rat liver was reported to resemble human liver cirrhosis.
PrPSc in the liver was reported to be present within Kupffer cells at several stages of the BSE infection (M. Jeffrey, personal communication).
In Kacheliba, an enlarged liver was reported in 13.5% out of 2,130 cases, although lymph nodes were enlarged in only 1.3% of cases.
Chemistries used for solid-supported synthesis of ON conjugates for improved delivery and targeting of ON drugs have been reviewed, and recently a simplified method to synthesize trimeric GalNAc ligands for siRNA delivery to the liver was reported.
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