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We reported the HAF value at approximately 20% in normal rat livers (i.e., HAP : HPP = 1 : 4), indicating that CTP well reflected the hemodynamics of livers under normal physiological conditions.
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Transcriptional analysis showed that the highest mRNA expression level was in the liver under normal physiological conditions.
Both of these processes are physiological functions of the liver under normal conditions.
Hepatocytes remain in the quiescent G0 phase in the liver under normal conditions.
A list of all differentially expressed genes is available in Additional file 1 and Additional file 2 is a more detailed figure depicting TCPOBOP effects on mouse liver under normal and 1% cholesterol-containing diet.
In fact, in the liver under normal conditions, ROS are produced mainly as a by-product of aerobic respiration in hepatocytes mitochondria and in the plasma membrane of phagocytosing Kupffer cells.
Thus, it seems obvious that CK takes over specific functions in almost every cell of the body, except for liver, where under normal healthy conditions no CK is expressed (Wallimann and Hemmer 1994).
In this study, we demonstrated that VitC treatment induced HO-1 expression in the kidneys, liver, and lungs under normal condition and enhanced HO-1 expression after HS.
To examine the effect of VitC treatment on HO-1 expression in the liver, kidney, and lung under normal condition, rats were intraperitoneally injected with VitC (100 mg/kg body weight, Sigma, St . Louis MO, USA), as described previously [ 23, 24].
The yabB::tetRA mutant was undetectable in liver or spleen of animals under normal diet, while in mice under diet including CTet, yabB::tetRA invaded at a level comparable to the WT in mice under normal diet.
However, Fcor is expressed little in liver of wild-type mice under normal chow diet.
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