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Although those features are useful for the enrichment of true miRNA targets in general, the criteria for filtering may have nothing to do with HCV infection in human livers, the primary biological interest here.
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Many tissues outside the liver (the primary source of complement) synthesise a variety of complement proteins, either constitutively or response to noxious stimuli.
APAP induced LTB4 production in the liver, the primary target organ in APAP toxicity.
BaP is then carried to the liver, the primary site of systemic metabolism, via hepatic portal circulation.
The effects of folic acid on the liver, the primary organ for folate metabolism, are largely unknown.
One of alcohol's principal actions is damage to the liver, the primary organ for its metabolism.
The potential for iron damage is particularly high in liver, the primary organ for storage of excess iron [ 2].
In the liver, the primary site of AT synthesis, ATZ accumulation causes liver fibrosis and carcinogenesis by a gain-of-function mechanism (Hidvegi et al., 2010).
SHBG is produced in the liver, the primary site of action of the statins, but the mechanism by which statins could alter SHBG is unknown.
Following the analysis of these pluripotent EC cells, we decided to investigate these effects in the HepG2 cell line which arose from a carcinoma of the human liver, the primary organ for cholesterol and fatty acid metabolic processes.
Published studies of apoptosis induction by methylmercury involved neurological [ 18] and reproductive systems [ 19], so it is not necessarily unexpected to observe the opposite response in the liver, the primary site of detoxification.
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