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This study investigates in perfused pig livers the effect of the antioxidant idebenone and of cold ischemia time on the gene expression of c-fos and c-jun.
Despite the marked changes in membrane composition in L-Lpcat3 KO livers, the effect on gene expression was surprisingly limited.
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Effectively, in [52] the model in Eq. (7) simulates in rat liver the effect of plasma concentration of a corticosteroid drug after a single intravenous administration of 50 mg/kg.
In the liver, the effect of transgene expression on the accumulation of replication intermediates was rather mild.
In the case of the liver, the effect of IPC was first described in 1993 in an experimental rat model [ 14], with improved rat survival and liver function in the rodents subjected to IPC prior to 90 minutes of ischemia.
As propofol clearance is limited by the blood flow through the liver, the effect of both TBW and age on propofol may be explained by changes in liver blood flow.
Although sirtuin 1 (Sist1) implicatedted in the regulation of gluconeogenesis in the liver, the effects of other histone deacetylases (HDAC) on gluconeogenesis are unclear.
In the liver, the effects of GW501516 were highly conserved when delivered concurrently with PF-879, and of note, FGF21 was significantly increased.
In brain and liver, the effects of HCE were analyzed at 48 h and 6 h after acute exercise, respectively.
In the liver, the effects were lower with decreased insulin-stimulated tyrosine phosphorylation of the insulin receptor (Batista et al., 2012).
It inhibited neither appetite nor growth and did not cause histological changes except in the liver, where the effect was actually beneficial (prevention of fatty liver).
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