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Dexa5-Man10-HSA accumulated in livers of both healthy and fibrotic rats (67% ± 5% and 70% ± 9% of the dose, respectively) and uptake was found almost exclusively in KC.
No specific signal was noted in livers of both wild-type and transgenic mice.
In neonatal kidneys of 1- and 2-day-old mice, a staining pattern similar to that of 1- and 2-week-old mice was observed, whereby X-gal signal was noted in the developing kidneys of the transgenic mice but no signal was observed in the livers of both wild-type and transgenic mice (Figure S1Bi and data not shown).
A single injection of AdshHNF1α significantly decreased HNF1α expression in the livers of both models.
On the other hand, p53 expression was similar in livers of both mice strains independent of Fas treatment (Fig. 2C).
Interestingly, Ahrr and Cyp1b1 were altered in livers of both male and female mice only at later time points.
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Trams et al. evaluated the morphological and functional changes in the liver of rats both after ligation (without division) and excision of the common bile duct [ 3].
Concurrently, a depletion of GSH was found in the liver of both Cd-treated (67% of controls) and Cd plus curcumin-treated mice (54% of controls).
The liver of both larval and adult zebrafish showed severe damage after exposure to Cu2 + at a concentration of 5 μM.
Upon T3 treatment, the activity of this enzyme decreased in the liver of both animal models, while in the kidney it was not affected by the hormone.
We observed that Lcn2 expression is increased in the liver of both Hfe−/− mice and those with dietary iron overload, suggesting that this induction is iron-related.
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