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Defective autophagosome-lysosome fusion has also been reported in livers from high fat diet- (HFD-) induced obese mice.
Values are means ± SEM. (F – G ) Hematoxylin and eosin staining (F ) and lipid contents (G ) of livers from high sucrose diet-fed Lpcat 3fl/fl (F/F) and Lpcat3fl/fl Albumin-Cre (L-KO) mice.
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The expression of miR-21 was decreased in liver from high-fat diet-fed mice compared to chow fed mice.
Task force analysts think the condition was actually angiosarcoma of the liver resulting from high vinyl chloride monomer exposure.
Furthermore, saturation of the exportin-5 machinery is known to contribute to the toxicity in liver resulting from high expression of shRNA in mouse [ 144].
Total n-3 PUFA and n-3 LC-PUFA were higher in the liver from the high silage fed bulls, when compared to those fed the low silage diet (P < 0.001).
Hepatic lipase plays an important role in plasma lipoprotein metabolism and intracellular lipid homeostasis [ 21], by mediating cholesterol influx into liver cells from high-density lipoproteins (HDL), and clearance of remnant lipoproteins from the circulation by the liver.
33 Therefore, it seemed prudent to exclude central liver tumors from high-dose single-fraction treatments, although a separate clinical study, or possibly preclinical study, would be necessary to determine if the structures in the hilum of the liver exhibit sensitivity similar to the lung hilum.
In order to minimize effects resulting from high liver uptake of FAZA, aorta ROIs were contoured from the same range of PET/CT slices (along the cranial-caudal axis) as the tumour ROIs.
These deposits can protect the liver and skeletal muscle from high exposure to free fatty acids and their uptake with subsequent fatty infiltration.
Of note, purified hepatocytes from livers with high percentage of Yap high cells did not have elevated IL-6 levels (Author response image 1, bottom right panel).
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