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Moreover, more PEI-D-GlcNAc-ICG/siRNA was distributed in fibrotic livers compared to the control complex that was absent of GlcNAc ligand.
The optical images presented (Figure 1a) show a relatively weaker signal at the tumors and livers compared to the PET images (Figure 1b), but this is mostly related to the modality employed.
Furthermore, it was demonstrated that PHMPs had a significant protective effect against oxidative stress induced by d-galactose in mice, as evident by higher activities of superoxide dismutase, catalase, glutathione peroxidase and level of total antioxidant capacity, as well as lower levels of malondialdehyde in serums and livers compared to the d-galactose-treated group.
Mfn2 protein levels were reduced by 65% in KO livers compared to the control group (Fig. 6A).
Genes related to liver inflammation and fibrosis were found to be elevated in NASH livers compared to normal livers.
Fifteen minute measurements of the rates of fatty acid oxidation demonstrated reduced capacity for oxidation in the fasted Pank1−/− livers compared to fasted wild-type livers (Fig. 3D).
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CCl4 administration in rats also increased APOP development in plasma and in liver compared to control rats significantly (p < 0.0001).
We observed a weakly elevated uptake of QE in the liver compared to the free DY-754.
On the other hand, selenite administered to the normal mice reduced GSH levels in the liver compared to the controls.
LTSL showed higher affinity for the liver compared to TTSL and NTSL which were uptaken mainly by spleen.
CCl4-treated rats also showed decreased in liver wet weight; however, Citrus macroptera supplementation did not change the wet weight of the liver compared to the control.
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