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A comparative histopathological study of liver exhibited almost a normal liver lobular architecture and cell structure of the livers, as compared to CCl4-treated group.
Heat-stressed birds had increased (P < 0.05) serum concentrations of corticosterone, endotoxin lipopolysaccharide and the systemic inflammatory cytokine: TNF-α and IL-2, as well as a higher (P < 0.05) prevalence of Salmonella spp. in meat and livers, as compared with control treatment.
In particular, the sigV mutant exhibited a reduction of 1.51 logs (p = 0.0058) in kidneys and of 1.37 logs (p = 0.0155) in livers as compared to the JH2-2 wild-type strain.
At the protein level by immunohistochemisty, we showed significantly less nuclear p21 immunostaining at baseline in rAd.A20 treated livers, as compared to rAd.βgal treated controls, which conversely translated in significant increase of proliferating hepatocytes, as indicated by the number of Ki67 positive cells in rAd.A20, as compared to rAd.βgal treated livers, 48 hrs after resection (Fig. 6B).
Predictably, mice implanted with Qtracker 565-labeled Panc02 cells and treated with a single intraperitoneal injection of anti-ANXA2 antibody were found to have significantly (p<0.0001) fewer Qtracker 565-positive cells in their livers as compared with mice given the control mAb (Figure 5B,C).
Additionally, we found that the percentage for each category of transcript of total normalized counts is generally more variable for old livers as compared to young (Fig. 2e).
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Both dimers presented slightly higher blood retention and a significantly increased uptake in the spleen, lungs, kidney and liver as compared to the monomer.
Water-stirred-nC60 elevated LPO in brain, significantly increased LPO in gill, and significantly increased expression of CYP2 family isozymes in liver as compared to control fish.
Similarly, mice infected with A2 strains had significantly higher bacterial loads in the blood and liver as compared to A1a and A1b infected mice.
These studies provided evidence that during late stages of HCV induced liver disease many of the changes in gene expression observed between HCV-infected liver as compared to control liver biospecimens are due to liver fibrosis and not HCV infection.
CYP3A43 is expressed at relatively low levels in liver as compared to CYP3A4, expression of CYP3A43 mRNA was about 0.1% of CYP3A4 in human liver samples (Fig 3b) while in the brain CYP3A43 expression is relatively higher (Fig 3a).
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