Sentence examples for livers are protected from inspiring English sources

Chronically injured MeCP2 knockout livers are protected from fibrosis, which may be in part related to significantly reduced ASH1 expression and consequent diminution of profibrogenic genes collagen I, TIMP-1, and TGF-β1 (Fig. 5C,D).

As a result, PTP1B-deficient livers are protected against APAP-induced oxidative stress and injury as manifested by decreased GSH depletion favoring NAPQI detoxification and subsequently limiting the formation of APAP protein adducts.

On the other hand, transgenic mice that have been engineered to express mtCK in their liver are protected from apoptosis and its destructive consequences by simple addition of Cr or its analogue cyclocreatine that is also phosphorylated by the CK reaction (Fig.  4).

Additionally, in line with an improvement in hyperinsulinemia, liver-CaMKII- or liver-p38ɑ-inhibited mice are protected from fatty liver formation and exhibit lower plasma triglyceride levels.

In NAFLD, PPAR γ is upregulated in liver tissue and liver-specific PPAR γ knockout mice are protected from diet-induced steatosis [ 36, 37].

36, 37 Studies in our laboratory have described an epigenetic relay pathway that must be activated in order to drive HSC transdifferentiation. 37 Mice lacking MeCP2 are protected from liver fibrosis and mecp2-deficient HSC display multiple defects in their fibrogenic phenotype including reduced expression of collagen I, TIMP-1, and α-SMA.

Moreover, Nrf2-disrupted mice are more susceptible to steatosis and steatohepatitis after MCD diet [ 31] whereas Keap1 hypomorphic are protected from this liver damage [ 32].

Histopathological examination of zebrafish liver showed that young female zebrafish are protected from the development of fibrosis, whereas all the other groups (young and old male fish, and old female fish) are not, thus reinforcing the hypothesis of a protective effect of estrogens and of a role for ovarian senescence in the development of hepatic fibrosis.

Transgenic mice over-expressing Cyp7a1 are protected from high-fat diet induced obesity, fatty liver and insulin resistance [ 72].

Shearer et al. (2005) found that Fabp4-null mice are protected against diet-induced obesity, insulin resistance, and fatty liver.

Nod1/Nod2-double-KO mice are protected from HFD-induced insulin intolerance, lipid accumulation and inflammation in adipose tissue and liver.