While it was suggested that this virus may target the liver –a finding confirmed in our animal model in the first hours of infection–, acute hepatitis seems to be mainly promoted by chronic ethylism, denutrition and paracetamol toxicity [32].
Tsuneto et al. showed a borderline significant independent association between blood pressure and fatty liver, a finding that was not confirmed in our study.
Because PEDF is most highly expressed by the liver, a finding recently confirmed in the Human Protein Atlas, and modulates Wnt/ β-catenin signaling, we asked whether PEDF functions as an LRP6 antagonist in the liver.
Interestingly, the promoter region of Hnf4a near the transcription start site is suggested to behave like an organ-specific differentially methylated region (T-DMR) and found to be hypomethylated in the liver, a finding which was supported by our data.
Moreover, in the OLT group, plasma clearance increased significantly after transplantation and during liver reperfusion, a finding which supports the hypothesis that the liver is the principal site of rFVIIa metabolism [ 28].
More important than an effect on aminotransferase levels, increasing coffee and caffeine consumption has been found to be associated with reduced liver fibrosis, a finding that has been largely consistent across studies in HCV and fatty liver disease, whether related to NASH or alcohol.
In the second case, we report what we call the "liver sign" a finding in patients with pneumoperitoneum.
On the other hand, the SPECT images revealed a substantial uptake of 111In-RGD-MSAP in other regions of the mouse, e.g. the liver and kidneys, a finding that correlates with previously reported biodistribution studies [30].
In addition, toxicity was associated with the functional liver dose DFL-TOT, a finding consistent with existing understanding of radiation hepatotoxicity [ 27].
On the other hand, the injection of apatite particles has been shown to be fatal to Wistar rats as it induces infarction and acute thrombosis of blood vessels in major organs like the liver and the lungs [109], a finding thought to mimic clinical settings in which unstable atherosclerotic lesions are also known to produce thrombosis and even myocardial infarction.
